pakistan

4-Arylamino-6-nitroquinazolines: Synthesis and their activities against neglected disease leishmaniasis.

ABSTRACT - 4-Arylamino-6-nitroquinazolines (2-25) were synthesized and evaluated for their
leishmanicidal activities against Leishmania major promastigotes in vitro with
IC50 values = 1.87-61.48 muM. Among the twenty four synthetic derivatives,
4-[4'-(methylsulfanyl)phenyl]amino-6-nitroquinazoline (21), and
4-(2'-methoxyphenyl)amino-6-nitroquinazoline (8) showed excellent antileishmanial
activities with IC50 values 1.87 +/- 0.31 and 4.37 +/- 0.02 muM, respectively,

About Us

A Platform for experts to develop and test evidence based strategies for the treatment and control of Leishmaniasis.

 

Social media

Contact Us

SECID - Rruga Aleksander Moisiu, Nr. 80, Tirana, Albania 

Tel. +355 68 20 69 698 
Fax. +355 4370058