Size does matter: 18 amino acids at the N-terminal tip of an amino acid transporter in Leishmania determine substrate specificity



4-Arylamino-6-nitroquinazolines: Synthesis and their activities against neglected disease leishmaniasis.

ABSTRACT - 4-Arylamino-6-nitroquinazolines (2-25) were synthesized and evaluated for their
leishmanicidal activities against Leishmania major promastigotes in vitro with
IC50 values = 1.87-61.48 muM. Among the twenty four synthetic derivatives,
4-[4'-(methylsulfanyl)phenyl]amino-6-nitroquinazoline (21), and
4-(2'-methoxyphenyl)amino-6-nitroquinazoline (8) showed excellent antileishmanial
activities with IC50 values 1.87 +/- 0.31 and 4.37 +/- 0.02 muM, respectively,

Genetic diversity and structure in Leishmania infantum populations from southeastern Europe revealed by microsatellite analysis

Background: The dynamic re-emergence of visceral leishmaniasis (VL) in south Europe and the northward shift to
Leishmania-free European countries are well-documented. However, the epidemiology of VL due to Leishmania
infantum in southeastern (SE) Europe and the Balkans is inadequately examined. Herein, we aim to re-evaluate and
compare the population structure of L. infantum in SE and southwestern (SW) Europe.
Methods: Leishmania strains collected from humans and canines in Turkey, Cyprus, Bulgaria, Greece, Albania and

Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern

Abstract. Phlebotomine sandflies transmit pathogens that affect humans and animals
worldwide. We review the roles of phlebotomines in the spreading of leishmaniases,
sandfly fever, summer meningitis, vesicular stomatitis, Chandipura virus encephalitis
and Carri´on’s disease. Among over 800 species of sandfly recorded, 98 are proven or
suspected vectors of human leishmaniases; these include 42 Phlebotomus species in
the Old World and 56 Lutzomyia species in the New World (all: Diptera: Psychodidae).



Živičnjak, T.,* Martinković, F.,* Pinter, Lj.,** Ivšić Škoda, D.,***
* University of Zagreb, Faculty of Veterinary Medicine, Department of Parasitology and Parasitic Diseases with Clinic; Heinzelova 55; 10000 Zagreb, Croatia;
** University of Zagreb, Faculty of Veterinary Medicine, Department of Microbiology and Infective Diseases With Clinic
*** University of Zagreb, Faculty of Veterinary Medicine, Internal Diseases Clinic


Diagnosis of Visceral Leishmaniasis by Fine Needle Aspiration Cytology of an Isolated Cervical Lymph Node: Case Report

A 61-year-old woman presented with an isolated, painless, slightly enlarged right laterocervical lymph node without
any other signs and symptoms of disease. Laboratory test including hematological and biochemical parameters were
normal. A cervical ultrasonography demonstrated one lymph node (10 mm) on the right laterocervical side and one
small reactive lymph node on the left laterocervical side. The fine needle aspiration (FNA) smears revealed a polymorphic


Leishmaniasis acquired by travellers to endemic regions in Europe - a EuroTravNet multi-centre study

Leishmaniasis is a disease caused by protozoan parasites which belong to the genus
Leishmania. Important clinical manifestations of leishmaniasis include cutaneous
leishmaniasis (CL) and visceral leishmaniasis (VL). Currently, leishmaniasis occurs in all
continents with the exception of Antarctica and is considered to be endemic in 88
countries. About 90% of cases with leishmaniasis occur in the tropics or subtropics but
the disease is also endemic in the Mediterranean area including countries like


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