VBORNET Newsletter 8, special issue ‘SAND FLIES’, July 2010

1. Phlebotominae sand flies (Diptera: Psychodidae): Main vectors in Europe and their distribution with special emphasis for Turkey
2. The leishmaniasis in southern Europe
3. Public health importance and control of sand flies in continental Europe
4. Sand fly species as new vector candidates for Leishmania transmission in Europe
5. Sandfly bites, saliva and gut secretions: Could it contribute to disease control?


Evaluation of clinical and laboratory findings of adult visceral leishmaniasis cases.

Mikrobiyol Bul. 2015 Oct;49(4):586-593.
[Article in Turkish]
Ural S1, Kaptan F, Sezak N, El S, Örmen B, Türker N, Demirdal T, Vardar İ, Özkan Çayıröz P, Çakalağaoğlu F.
Author information

1Izmir Katip Celebi University Atatürk Training and Research Hospital, Infectious Diseases Clinic, Izmir, Turkey.




Visceral leishmaniasis (VL) is caused by the dissemination of the
protozoan parasite Leishmania donovani throughout the reticuloendothelial
system. This systemic disease may mimic or lead to
several types of hematological disorders including hemophagocytic
lymphohistiocytosis (HLH). Infection associated hemophagocytic
syndrome caused by Leishmania is very rare and difficult
to diagnose. Herein, we describe an infant with HLH associated
with VL. The severity of HLH secondary to visceral leishmaniasis


The past, present, and future of Leishmania genomics and transcriptomics

It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite.Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite–host–vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to

Visceral leishmaniasis as a possible reason for pancytopenia

Leishmaniasis is caused by different species of the protozoa, Leishmania, and frequently found in South-Western Asia, Eastern Africa, Brazil, and Mediterranean countries. Leishmania are transmitted to humans by the bite of sandflies. After weeks to months, unspecific symptoms may occur, accompanied by more specific findings like pancytopenia and organomegaly.



Background: Visceral leishmaniasis, also known as kala-azar, is a vector borne disease caused by the
protozoan parasite, L. donovani. It is endemic in areas bordering the Mediterranean Sea. Untreated visceral
leishmaniasis has fatal course. Therefore, early diagnosis and specific therapy with pentavalent antimony
drugs are mandatory.
The aim of this study was to analyze patients hospitalized for investigation of hepatosplenomegaly that
turned out to be visceral leishmaniasis.


4-Arylamino-6-nitroquinazolines: Synthesis and their activities against neglected disease leishmaniasis.

ABSTRACT - 4-Arylamino-6-nitroquinazolines (2-25) were synthesized and evaluated for their
leishmanicidal activities against Leishmania major promastigotes in vitro with
IC50 values = 1.87-61.48 muM. Among the twenty four synthetic derivatives,
4-[4'-(methylsulfanyl)phenyl]amino-6-nitroquinazoline (21), and
4-(2'-methoxyphenyl)amino-6-nitroquinazoline (8) showed excellent antileishmanial
activities with IC50 values 1.87 +/- 0.31 and 4.37 +/- 0.02 muM, respectively,


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