The past, present, and future of Leishmania genomics and transcriptomics

ABSTRACT
It has been nearly 10 years since the completion of the first entire genome sequence of a Leishmania parasite.Genomic and transcriptomic analyses have advanced our understanding of the biology of Leishmania, and shed new light on the complex interactions occurring within the parasite–host–vector triangle. Here, we review these advances and examine potential avenues for translation of these discoveries into treatment and control programs. In addition, we argue for a strong need to
explore how disease in dogs relates to that in humans,and how an improved understanding in line with the
‘One Health’ concept may open new avenues for the control of these devastating diseases.

Cinzia Cantacessi1, Filipe Dantas-Torres2,3, Matthew J. Nolan4, and
Domenico Otranto3
1 Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
2 Departamento de Imunologia, Centro de Pesquisas Aggeu Magalha˜ es, Fiocruz-PE, Brazil
3 Dipartimento di Medicina Veterinaria, Universita` degli Studi di Bari, Bari, Italy
4 Royal Veterinary College, University of London, North Mymms, UK

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