FIRST CASE OF VISCERAL LEISHMANIOSIS/HIV COINFECTION IN NIŠ – SOUTHEASTERN SERBIA

Abstract - Visceral leishmaniosis (VL) has emerged as an important opportunistic parasitosis associated with human immunodeficiency
virus (HIV) infection. The aim of this paper is to report the first case of Leishmania/HIV coinfection in
a patient from Niš (Southeastern Serbia). Microscopical examination of Giemsa-stained bone marrow (BM) smears show
the presence of Leishmania spp. amastigotes based on their morphological characteristics. In spite of the parasitological
finding, the serological test applied gave negative results. Molecular analyses confirmed the infection and allowed us
to identify the leishmania species as Leishmania infantum (100% identity). VL/HIV coinfection has important clinical,
diagnostic and epidemiological implications. In fact, the failure of serological tests is expected in this condition, and the
application of molecular diagnostics to the blood may offer, apart from an easy and non-invasive diagnostic opportunity,
the possibility of warning about the risk of possible nosocomial infections.

Key words: Visceral leishmaniosis, HIV co-infection, molecular diagnosis

Authors
G. MARJANOVIĆ1,4, NATAŠA MILADINOVIĆ TASIĆ1,2, SIMONA GABRIELLI3,
SUZANA OTAŠEVIĆ1,2, LIDIJA POPOVIĆ DRAGONJIĆ1,4, BRANISLAVA KOCIĆ1,2,
VALENTINA ARSIĆ ARSENIJEVIĆ5, LJILJANA TADIĆ6 and GABRIELLA CANCRINI3
1 University of Niš, Medical Faculty of Niš, 18000 Niš, Serbia
2 Institute of Public Health Niš, 18000 Niš, Serbia
3 “Sapienza” University of Rome, Medical Faculty, Rome Italy
4 Clinical Center Niš, 18000 Niš, Serbia
5 University of Belgrade, Medical Faculty, 11000 Belgrade, Serbia
6 Military Hospital, 18000 Niš, Serbia

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