Leishmaniasis in dogs is a serious protozoan zoonosis that infects millions worldwide. Dogs and
human get infected by leishmania promastigotes induced by bite of infected sand fl y Phlebotomus
spp. Promastigotes multiply into the macrophages as intracellular amastigotes. Clinical signs may
appear months or years after the infection (10).Visceral leishmaniasis or Kala-azar is a lifethreatening
disease that has medical, social and economic importance in the endemic areas. Dogs
are the main reservoir for Leishmania infantum.The clinical fi ndings are very different which
impedes the diagnosis. Some dogs show clinical
Canine leishmaniasis (CanL) due to Leishmania infantum and canine monocytic ehrilichiosis (CME) due to
Ehrlichia canis are common diseases with zoonotic potential in the Mediterranean area. Their prevalence in R.
Macedonia as a neighboring Mediterranean county is expected. In both diseases similar clinical symptoms can be
manifested in dogs such as: lethargy, anorexia, weight loss, epistaxis, fever, pale mucous membranes, enlarged
lymph nodes, splenomegaly, ocular signs. This case report present an atypical case of 11 year old female Samoyed
with starting single clinical symptom epistaxys. Initial diagnostic procedures revealed the presence only of CanL,
which was diagnosed using indirect immunofl uorescence method and ELISA. First laboratory fi ndings showed
normal hematological and renal profi les. Dog was put on a treatment with Allopurinol (20mg/kg, p/o) for at least
9 months. Termination of the therapy after 6 months brought a numerous clinical symptoms involving weakness,
dehydration, pale mucous membranes lost pupilar refl ex, uremic breath and biochemical parameters revealed a
renal failure. Using a commercial ELISA kit Ehrlichia canis as a co-infection was diagnosed. Most probably the
second infectious agent was induced in the past 6 months, causing more severe pathological effects than CanL
infection alone.
Key words: L. infantum, Ehrichia canis, dog, IFAT, ELISA,
Atanaskova Elena1, Kocevski Zoran2, Nikolovski Goran1, Stefanovska Jovana2
1Department of internal diseases of companion animals and horses at the
Faculty of Veterinary Medicine in Skopje;
2 Department of Parasitology and parasitic diseases at the
Faculty of Veterinary Medicine in Skopje;


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